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William Henry Westra, MD

William Henry Westra, MD 病理学教授

所在科室：耳鼻喉科

就职医院：约翰霍普金斯医院（johns Hopkins Hospital）

医生擅长：分子基因技术的应用对于早期头部、颈部癌症的诊断和检查，头部和颈部癌症的分子遗传学进展，甲状腺肿瘤的形成

在线咨询医学顾问 电话热线：400-666-7998

医生介绍


William Henry Westra博士是约翰霍普金斯医院、约翰霍普金斯医院大学医学院。头颈病理学实验室主任，肿瘤病理学教授，皮肤科副教授，肿瘤学教授，耳鼻喉—头颈外科教授。现就职于该医院Sidney Kimmel 综合 癌症中心，主要从事癌症病理学的研究。
1995年Dr. Westra创建了该医院的头部颈部病理学实验室，从这个时候他开始联合心肺病理学实验室进行有关分子生物学检查、诊断头颈部癌症的临床研究试验研究。许多非常有前景的跨学科临床试验在他的主持和指导下，顺利进行。他还开启了实验室的对外诊断服务，为病人带来早期治疗和确诊癌症的机会。
William Henry Westra于佛罗里达医学院获得临床病理学博士学位，在约翰霍普金斯医院完成了他的住院医师工作。他在纪念斯隆凯特琳癌症研究中心从事研究员工作，并在之后返回约翰霍普金斯医院在外科病理科担任首席临床研究员。
Dr. Westra研究兴趣主要包括分子基因学技术在早期诊断头颈部癌症的应用。
Dr. Westra是《外科病理解剖学》合著者之一，这本教材详细介绍了复杂的头部、颈部肿瘤切除术评估的最新方法和技术。他主持和指导美国国家卫生研究所资助的“卓越研究专门项目”。
会员资格：
约翰霍普金斯大学医学院，病理组织/标本应用委员会会员
教育经历：
培训：
佛罗里达大学医学院（盖恩斯维尔，佛罗里达州）（1990）
住院医师：
约翰霍普金斯医学院/病理学博士（巴尔的摩）（1994）
约翰霍普金斯医学院/病理学博士（巴尔的摩）（1993）
研究员经历：
约翰霍普金斯医学院/病理学博士（巴尔的摩）（1994）
约翰霍普金斯医学院/病理学博士（巴尔的摩）（1993）
医学领域执照：
美国病理学委员会委员，美国解剖病理学委员会委员
Dr. Westra的研究聚焦于头部和颈部癌症的检测。他是上呼吸到肿瘤学专家，同事也对甲状腺癌发病的病理学机制有深入的研究。作为约翰霍普金斯医院“头部颈部癌症美国国家癌症研究院项目“的研究主持者，他潜心于研究人类乳头瘤病毒(HPV)在癌症发病中的作用以及这种病毒是如何转移到上呼吸到的机制。
发表的主要论文/出版物：
    1. Alphs, H.H.; Eisele, D.W.; Westra, W.H. The role of fine needle aspiration in the evaluation of parotid masses. Curr Opin Otolaryngol Head Neck Surg. 2006 Apr;14(2):62-66.
    2. da Motta, A.C.; Tunkel, D.E.; Westra, W.H.; Yousem, D.M. Imaging findings of a hibernoma of the neck. Ajnr. 2006 Sep;27(8):1658-1659.
    3. Dodd, L.E.; Sengupta, S.; Chen, I.H.; den Boon, J.A.; Cheng, Y.J.; Westra, W.; Newton, M.A.; Mittl, B.F.; McShane, L.; Chen, C.J.; Ahlquist, P.; Hildesheim, A. Genes involved in DNA repair and nitrosamine metabolism and those located on chromosome 14q32 are dysregulated in nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2216-2225.
    4. Hoque, M.O.; Begum, S.; Topaloglu, O.; Chatterjee, A.; Rosenbaum, E.; Van Criekinge, W.; Westra, W.H.; Schoenberg, M.; Zahurak, M.; Goodman, S.N.; Sidransky, D. Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. J Natl Cancer Inst. 2006 Jul 19;98(14):996-1004.
    5. Hosler, G.A.; Clark, I.; Zakowski, M.F.; Westra, W.H.; Ali, S.Z. Cytopathologic analysis of thyroid lesions in the pediatric population. Diagnostic cytopathology. 2006 Feb;34(2):101-105.
    6. Hu, S.; Liu, D.; Tufano, R.P.; Carson, K.A.; Rosenbaum, E.; Cohen, Y.; Holt, E.H.; Kiseljak-Vassiliades, K.; Rhoden, K.J.; Tolaney, S.; Condouris, S.; Tallini, G.; Westra, W.H.; Umbricht, C.B.; Zeiger, M.A.; Califano, J.A.; Vasko, V.; Xing, M. Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. Int J Cancer. 2006 Nov 15;119(10):2322-2329.
    7. Jiang, W.W.; Rosenbaum, E.; Mambo, E.; Zahurak, M.; Masayesva, B.; Carvalho, A.L.; Zhou, S.; Westra, W.H.; Alberg, A.J.; Sidransky, D.; Koch, W.; Califano, J.A. Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. Clin Cancer Res. 2006 Mar 1;12(5):1564-1569.
    8. Jiang, W.W.; Zahurak, M.; Goldenberg, D.; Milman, Y.; Park, H.L.; Westra, W.H.; Koch, W.; Sidransky, D.; Califano, J. Increased plasma DNA integrity index in head and neck cancer patients. Int J Cancer. 2006 Dec 1;119(11):2673-2676.
    9. Pai, S.I.; Goldstein, B.J.; Studeman, K.D.; Westra, W.H.; Tufano, R.P. Concurrent sporadic parathyroid adenoma and carcinoma. Am J Otolaryngol. 2006 Sep-Oct;27(5):346-348.
    10. Sengupta, S.; den Boon, J.A.; Chen, I.H.; Newton, M.A.; Dahl, D.B.; Chen, M.; Cheng, Y.J.; Westra, W.H.; Chen, C.J.; Hildesheim, A.; Sugden, B.; Ahlquist, P. Genome-Wide expression Profiling Reveals EBV-Associated Inhibition of MHC Class I expression in Nasopharyngeal Carcinoma. Cancer Res. 2006 Aug 15;66(16):7999-8006.
    11. Thunnissen, F.B.; Kerr, K.M.; Brambilla, E.; Comin, C.E.; Franklin, W.A.; Guldhammer, B.; Westra, W.H.; Flieder, D.B. EU-USA pathology panel for uniform diagnosis in randomised controlled trials for HRCT screening of lung cancer. Eur Respir J. 2006 Aug 9;28:1186-1189.
    12. Upadhyay, S.; Liu, C.; Chatterjee, A.; Hoque, M.O.; Kim, M.S.; Engles, J.; Westra, W.; Trink, B.; Ratovitski, E.; Sidransky, D. LKB1/STK11 Suppresses Cyclooxygenase-2 Induction and Cellular Invasion through PEA3 in Lung Cancer. Cancer Res. 2006 Aug 15;66(16):7870-7879.
    13. Westra, W.H.; Sidransky, D. Fluorescence visualization in oral neoplasia: shedding light on an old problem. Clin Cancer Res. 2006 Nov 15;12(22):6594-6597.
    14. Begum, S.; Gillison, M.L.; Nicol, T.L.; Westra, W.H. Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res. 2007 Feb 15;13(4):1186-1191.
    15. D'Souza, G.; Kreimer, A.R.; Viscidi, R.; Pawlita, M.; Fakhry, C.; Koch, W.M.; Westra, W.H.; Gillison, M.L. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007 May 10;356(19):1944-1956.
    16. Lietman, S.A.; Prescott, N.L.; Hicks, D.G.; Westra, W.H.; Levine, M.A. SH3BP2 Is Rarely Mutated in Exon 9 in Giant Cell Lesions Outside Cherubism. Clin Orthop Relat Res. 2007 Jun;459:22-27.
    17. Liu, C.; Zhou, S.; Begum, S.; Sidransky, D.; Westra, W.H.; Brock, M.; Califano, J.A. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. Lung Cancer. 2007 Mar;55(3):303-311.
    18. Mithani, S.K.; Taube, J.M.; Zhou, S.; Smith, I.M.; Koch, W.M.; Westra, W.H.; Califano, J.A. Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4331-4335.
    19. Nayak, C.S.; Carvalho, A.L.; Jeronimo, C.; Henrique, R.; Kim, M.M.; Hoque, M.O.; Chang, S.; Jiang, W.W.; Koch, W.; Westra, W.; Sidransky, D.; Califano, J. Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma. Laryngoscope. 2007 Aug;117(8):1376-1380.
    20. Poeta, M.L.; Manola, J.; Goldwasser, M.A.; Forastiere, A.; Benoit, N.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007 Dec 20;357(25):2552-2561.
    21. Shah, K.V.; Westra, W.H. Genital HPVs in the aerodigestive tract: Etiologic association with a subset of oropharyngeal/tonsillar cancers and with recurrent respiratory papillomatosis. Disease markers. 2007;23(4):235-245.
    22. Taube, J.M.; Askin, F.B.; Brock, M.V.; Westra, W. Impact of elastic staining on the staging of peripheral lung cancers. Am J Surg Pathol. 2007 Jun;31(6):953-956.
    23. Westra, W.H. Diagnostic difficulties in the classification and grading of salivary gland tumors. Int J Radiat oncol Biol Phys. 2007;69(2 Suppl):S49-51.
    24. Zhou, S.; Kachhap, S.; Sun, W.; Wu, G.; Chuang, A.; Poeta, L.; Grumbine, L.; Mithani, S.K.; Chatterjee, A.; Koch, W.; Westra, W.H.; Maitra, A.; Glazer, C.; Carducci, M.; Sidransky, D.; McFate, T.; Verma, A.; Califano, J.A. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7540-7545.
    25. Agrawal, Y.; Koch, W.M.; Xiao, W.; Westra, W.H.; Trivett, A.L.; Symer, D.E.; Gillison, M.L. Oral human papillomavirus infection before and after treatment for human papillomavirus 16-positive and human papillomavirus 16-negative head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Nov 1;14(21):7143-7150.
    26. Begum, S.; Westra, W.H. Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol. 2008;32:1044-1050.
    27. Borowitz, M.; Westra, W.H.; Illei, P.B.; Cooley, L.D.; Kant, J.A.; Sokoll, L.J.; Chan, D.W.; Sanfilippo, F. Pathology and Laboratory Medicine. In: Abeloff; Armitage; Kastan; Niederhuberl, editors. 4th ed, Clinical Oncology. Philadelphia: W.B. Saunders; 2008.
    28. Brait, M.; Begum, S.; Carvalho, A.L.; Dasgupta, S.; Vettore, A.L.; Czerniak, B.; Caballero, O.L.; Westra, W.H.; Sidransky, D.; Hoque, M.O. Aberrant Promoter Methylation of Multiple Genes during Pathogenesis of Bladder Cancer. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2786-2794.
    29. Carvalho, A.L.; Jeronimo, C.; Kim, M.M.; Henrique, R.; Zhang, Z.; Hoque, M.O.; Chang, S.; Brait, M.; Nayak, C.S.; Jiang, W.W.; Claybourne, Q.; Tokumaru, Y.; Lee, J.; Goldenberg, D.; Garrett-Mayer, E.; Goodman, S.; Moon, C.S.; Koch, W.; Westra, W.H.; Sidransky, D.; Califano, J.A. evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Jan 1;14(1):97-107.
    30. Chang, S.S.; Jiang, W.W.; Smith, I.; Poeta, L.M.; Begum, S.; Glazer, C.; Shan, S.; Westra, W.; Sidransky, D.; Califano, J.A. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer. 2008 Dec 15;123(12):2791-2797.
    31. Chuang, A.Y.; Chuang, T.C.; Chang, S.; Zhou, S.; Begum, S.; Westra, W.H.; Ha, P.K.; Koch, W.M.; Califano, J.A. Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncol. 2008 Oct;44(10):915-919.
    32. Fakhry, C.; Westra, W.H.; Li, S.; Cmelak, A.; Ridge, J.A.; Pinto, H.; Forastiere, A.; Gillison, M.L. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008 Feb 20;100(4):261-269.
    33. Gillison, M.L.; D'Souza, G.; Westra, W.; Sugar, E.; Xiao, W.; Begum, S.; Viscidi, R. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst. 2008 Mar 19;100(6):407-420.
    34. Goldenberg, D.; Begum, S.; Westra, W.H.; Khan, Z.; Sciubba, J.; Pai, S.I.; Califano, J.A.; Tufano, R.P.; Koch, W.M. Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 2008 Jul;30(7):898-903.
    35. Hoque, M.O.; Begum, S.; Brait, M.; Jeronimo, C.; Zahurak, M.; Ostrow, K.L.; Rosenbaum, E.; Trock, B.; Westra, W.H.; Schoenberg, M.; Goodman, S.N.; Sidransky, D. Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. J Urol. 2008 Feb;179(2):743-747.
    36. Hoque, M.O.; Kim, M.S.; Ostrow, K.L.; Liu, J.; Wisman, G.B.; Park, H.L.; Poeta, M.L.; Jeronimo, C.; Henrique, R.; Lendvai, A.; Schuuring, E.; Begum, S.; Rosenbaum, E.; Ongenaert, M.; Yamashita, K.; Califano, J.; Westra, W.; van der Zee, A.G.; Van Criekinge, W.; Sidransky, D. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res. 2008 Apr 15;68(8):2661-2670.
    37. Licchesi, J.D.; Westra, W.H.; Hooker, C.M.; Herman, J.G. Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung. Clin Cancer Res. 2008 May 1;14(9):2570-2578.
    38. Licchesi, J.D.; Westra, W.H.; Hooker, C.M.; Machida, E.O.; Baylin, S.B.; Herman, J.G. Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis. 2008 May;29(5):895-904.
    39. Park, H.L.; Kim, M.S.; Yamashita, K.; Westra, W.; Carvalho, A.L.; Lee, J.; Jiang, W.W.; Baek, J.H.; Liu, J.; Osada, M.; Moon, C.S.; Califano, J.A.; Mori, M.; Sidransky, D. DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int J Cancer. 2008 Jun 1;122(11):2498-2502.
    40. Prasad, N.B.; Somervell, H.; Tufano, R.P.; Dackiw, A.P.; Marohn, M.R.; Califano, J.A.; Wang, Y.; Westra, W.H.; Clark, D.P.; Umbricht, C.B.; Libutti, S.K.; Zeiger, M.A. Identification of genes differentially expressed in benign versus malignant thyroid tumors. Clin Cancer Res. 2008 Jun 1;14(11):3327-3337.
    41. Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most Basal-like Breast Carcinomas Demonstrate the Same Rb-/p16+ Immunophenotype as the HPV-related Poorly Differentiated Squamous Cell Carcinomas Which They Resemble Morphologically. Am J Surg Pathol. 2008 Oct 17.
    42. Taube, J.M.; Begum, S.; Shi, C.; Eshleman, J.R.; Westra, W.H. Benign Nodal Nevi Frequently Harbor the Activating V600E BRAF Mutation. Am J Surg Pathol. 2008 Nov 19.
    43. Wang, Y.; Kowalski, J.; Tsai, H.L.; Marik, R.; Prasad, N.; Somervell, H.; Lo, P.K.; Sangenario, L.E.; Dyrskjot, L.; Orntoft, T.F.; Westra, W.H.; Meeker, A.K.; Eshleman, J.R.; Umbricht, C.B.; Zeiger, M.A. Differentiating alternative splice variant patterns of human telomerase reverse transcriptase in thyroid neoplasms. Thyroid. 2008 Oct;18(10):1055-1063.
    44. Westra, W.H.; Taube, J.M.; Poeta, M.L.; Begum, S.; Sidransky, D.; Koch, W.M. Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p53 Gene Mutations in Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res. 2008 Jan 15;14(2):366-369.
    45. Zhao, M.; Begum, S.; Ha, P.K.; Westra, W.; Califano, J. Downregulation of RAD17 in head and neck cancer. Head Neck. 2008 Jan;30(1):35-42.
    46. Adelstein, D.J.; Ridge, J.A.; Gillison, M.L.; Chaturvedi, A.K.; D''Souza, G.; Gravitt, P.E.; Westra, W.; Psyrri, A.; Kast, W.M.; Koutsky, L.A.; Giuliano, A.; Krosnick, S.; Trotti, A.; Schuller, D.E.; Forastiere, A.; Ullmann, C.D. Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, D.C. Head Neck. 2009 Nov;31(11):1393-1422.
    47. Ostrow, K.L.; Park, H.L.; Hoque, M.O.; Kim, M.S.; Liu, J.; Argani, P.; Westra, W.; Van Criekinge, W.; Sidransky, D. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. 2009 Feb 15;15(4):1184-1191.
    48. Pai, S.I.; Westra, W.H. Molecular Pathology of Head and Neck Cancer: Implications for Diagnosis, Prognosis, and Treatment. Annu Rev Pathol. 2009 Aug 26;4:49-70.
    49. Poeta, M.L.; Manola, J.; Goldenberg, D.; Forastiere, A.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins. Clin Cancer Res. 2009 Dec 15;15(24):7658-7665.
    50. Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically. Am J Surg Pathol. 2009 Feb;33(2):163-175.
    51. Ang, K.K.; Harris, J.; Wheeler, R.; Weber, R.; Rosenthal, D.I.; Nguyen-Tan, P.F.; Westra, W.H.; Chung, C.H.; Jordan, R.C.; Lu, C.; Kim, H.; Axelrod, R.; Silverman, C.C.; Redmond, K.P.; Gillison, M.L. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010 Jul 1;363(1):24-35.
    52. Bishop, J.A.; Westra, W.H. Plasmablastic lymphoma involving the parotid gland. Head and neck pathology. 2010 Jun;4(2):148-151.
    53. Dasgupta, S.; Koch, R.; Westra, W.H.; Califano, J.A.; Ha, P.K.; Sidransky, D.; Koch, W.M. Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients. Cancer Prev Res (Phila). 2010 Sep;3(9):1205-1211.
    54. Durr, M.L.; Mydlarz, W.K.; Shao, C.; Zahurak, M.L.; Chuang, A.Y.; Hoque, M.O.; Westra, W.H.; Liegeois, N.J.; Califano, J.A.; Sidransky, D.; Ha, P.K. Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. PLoS One. 2010;5(5):e10828.
    55. Hoque, M.O.; Brait, M.; Rosenbaum, E.; Poeta, M.L.; Pal, P.; Begum, S.; Dasgupta, S.; Carvalho, A.L.; Ahrendt, S.A.; Westra, W.H.; Sidransky, D. Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer. J Thorac Oncol. 2010 Dec;5(12):1887-1893.
    56. Loyo, M.; Brait, M.; Kim, M.S.; Ostrow, K.L.; Jie, C.C.; Chuang, A.Y.; Califano, J.A.; Liegeois, N.J.; Begum, S.; Westra, W.H.; Hoque, M.O.; Tao, Q.; Sidransky, D. A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma. Int J Cancer. 2010 May 6.
    57. Loyo, M.; Guerrero-Preston, R.; Brait, M.; Hoque, M.O.; Chuang, A.; Kim, M.S.; Sharma, R.; Liegeois, N.J.; Koch, W.M.; Califano, J.A.; Westra, W.H.; Sidransky, D. Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission. Int J Cancer. 2010 Jun 15;126(12):2991-2996.
    58. Lyford-Pike, S.; Westra, W.H.; Loyo, M.; Peng, S.; Hung, C.F.; Wu, A.A.; Flint, P.W.; Tunkel, D.E.; Saunders, J.R.; Pai, S.I. Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis. Histopathology. 2010 Nov;57(5):768-770.
    59. Marur, S.; D''Souza, G.; Westra, W.H.; Forastiere, A.A. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 2010 Aug;11(8):781-789.
    60. Meguid, R.A.; Hooker, C.M.; Harris, J.; Xu, L.; Westra, W.H.; Sherwood, J.T.; Sussman, M.; Cattaneo, S.M., 2nd; Shin, J.; Cox, S.; Christensen, J.; Prints, Y.; Yuan, N.; Zhang, J.; Yang, S.C.; Brock, M.V. Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokers. Chest. 2010 Sep;138(3):500-509.
    61. Nichols, A.C.; Finkelstein, D.M.; Faquin, W.C.; Westra, W.H.; Mroz, E.A.; Kneuertz, P.; Begum, S.; Michaud, W.A.; Busse, P.M.; Clark, J.R.; Rocco, J.W. Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer. Clin Cancer Res. 2010 Apr 1;16(7):2138-2146.
    62. Singhi, A.D.; Westra, W.H. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer. 2010 May 1;116(9):2166-2173.
    63. Wang, C.C.; Friedman, L.; Kennedy, G.C.; Wang, H.; Kebebew, E.; Steward, D.L.; Zeiger, M.A.; Westra, W.H.; Wang, Y.; Khanafshar, E.; Fellegara, G.; Rosai, J.; Livolsi, V.; Lanman, R.B. A Large Multicenter Correlation Study of Thyroid Nodule Cytopathology and Histopathology. Thyroid. 2010 Dec 29.
在研临床试验：
Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx http://clinicaltrials.gov/show/NCT01088802
Immunologic Responses in HPV-Associated Carcinoma for Patients Receiving Chemoradiation http://clinicaltrials.gov/show/NCT01958515
核心设备：
Pathology Core Facility, Specialized Program of Research Excellence (SPORE) in Cancer of the Head and Neck
学术活动和荣誉：
《耳鼻喉科档案-头颈外科》专栏编辑

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William Henry Westra, MD

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William Henry Westra, MD 病理学教授

约翰霍普金斯医院（johns Hopkins Hospital） 耳鼻喉科

擅长

分子基因技术的应用对于早期头部、颈部癌症的诊断和检查，头部和颈部癌症的分子遗传学进展，甲状腺肿瘤的形成

简介


William Henry Westra博士是约翰霍普金斯医院、约翰霍普金斯医院大学医学院。头颈病理学实验室主任，肿瘤病理学教授，皮肤科副教授，肿瘤学教授，耳鼻喉—头颈外科教授。现就职于该医院Sidney Kimmel 综合 癌症中心，主要从事癌症病理学的研究。
1995年Dr. Westra创建了该医院的头部颈部病理学实验室，从这个时候他开始联合心肺病理学实验室进行有关分子生物学检查、诊断头颈部癌症的临床研究试验研究。许多非常有前景的跨学科临床试验在他的主持和指导下，顺利进行。他还开启了实验室的对外诊断服务，为病人带来早期治疗和确诊癌症的机会。
William Henry Westra于佛罗里达医学院获得临床病理学博士学位，在约翰霍普金斯医院完成了他的住院医师工作。他在纪念斯隆凯特琳癌症研究中心从事研究员工作，并在之后返回约翰霍普金斯医院在外科病理科担任首席临床研究员。
Dr. Westra研究兴趣主要包括分子基因学技术在早期诊断头颈部癌症的应用。
Dr. Westra是《外科病理解剖学》合著者之一，这本教材详细介绍了复杂的头部、颈部肿瘤切除术评估的最新方法和技术。他主持和指导美国国家卫生研究所资助的“卓越研究专门项目”。
会员资格：
约翰霍普金斯大学医学院，病理组织/标本应用委员会会员
教育经历：
培训：
佛罗里达大学医学院（盖恩斯维尔，佛罗里达州）（1990）
住院医师：
约翰霍普金斯医学院/病理学博士（巴尔的摩）（1994）
约翰霍普金斯医学院/病理学博士（巴尔的摩）（1993）
研究员经历：
约翰霍普金斯医学院/病理学博士（巴尔的摩）（1994）
约翰霍普金斯医学院/病理学博士（巴尔的摩）（1993）
医学领域执照：
美国病理学委员会委员，美国解剖病理学委员会委员
Dr. Westra的研究聚焦于头部和颈部癌症的检测。他是上呼吸到肿瘤学专家，同事也对甲状腺癌发病的病理学机制有深入的研究。作为约翰霍普金斯医院“头部颈部癌症美国国家癌症研究院项目“的研究主持者，他潜心于研究人类乳头瘤病毒(HPV)在癌症发病中的作用以及这种病毒是如何转移到上呼吸到的机制。
发表的主要论文/出版物：
    1. Alphs, H.H.; Eisele, D.W.; Westra, W.H. The role of fine needle aspiration in the evaluation of parotid masses. Curr Opin Otolaryngol Head Neck Surg. 2006 Apr;14(2):62-66.
    2. da Motta, A.C.; Tunkel, D.E.; Westra, W.H.; Yousem, D.M. Imaging findings of a hibernoma of the neck. Ajnr. 2006 Sep;27(8):1658-1659.
    3. Dodd, L.E.; Sengupta, S.; Chen, I.H.; den Boon, J.A.; Cheng, Y.J.; Westra, W.; Newton, M.A.; Mittl, B.F.; McShane, L.; Chen, C.J.; Ahlquist, P.; Hildesheim, A. Genes involved in DNA repair and nitrosamine metabolism and those located on chromosome 14q32 are dysregulated in nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2216-2225.
    4. Hoque, M.O.; Begum, S.; Topaloglu, O.; Chatterjee, A.; Rosenbaum, E.; Van Criekinge, W.; Westra, W.H.; Schoenberg, M.; Zahurak, M.; Goodman, S.N.; Sidransky, D. Quantitation of promoter methylation of multiple genes in urine DNA and bladder cancer detection. J Natl Cancer Inst. 2006 Jul 19;98(14):996-1004.
    5. Hosler, G.A.; Clark, I.; Zakowski, M.F.; Westra, W.H.; Ali, S.Z. Cytopathologic analysis of thyroid lesions in the pediatric population. Diagnostic cytopathology. 2006 Feb;34(2):101-105.
    6. Hu, S.; Liu, D.; Tufano, R.P.; Carson, K.A.; Rosenbaum, E.; Cohen, Y.; Holt, E.H.; Kiseljak-Vassiliades, K.; Rhoden, K.J.; Tolaney, S.; Condouris, S.; Tallini, G.; Westra, W.H.; Umbricht, C.B.; Zeiger, M.A.; Califano, J.A.; Vasko, V.; Xing, M. Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer. Int J Cancer. 2006 Nov 15;119(10):2322-2329.
    7. Jiang, W.W.; Rosenbaum, E.; Mambo, E.; Zahurak, M.; Masayesva, B.; Carvalho, A.L.; Zhou, S.; Westra, W.H.; Alberg, A.J.; Sidransky, D.; Koch, W.; Califano, J.A. Decreased mitochondrial DNA content in posttreatment salivary rinses from head and neck cancer patients. Clin Cancer Res. 2006 Mar 1;12(5):1564-1569.
    8. Jiang, W.W.; Zahurak, M.; Goldenberg, D.; Milman, Y.; Park, H.L.; Westra, W.H.; Koch, W.; Sidransky, D.; Califano, J. Increased plasma DNA integrity index in head and neck cancer patients. Int J Cancer. 2006 Dec 1;119(11):2673-2676.
    9. Pai, S.I.; Goldstein, B.J.; Studeman, K.D.; Westra, W.H.; Tufano, R.P. Concurrent sporadic parathyroid adenoma and carcinoma. Am J Otolaryngol. 2006 Sep-Oct;27(5):346-348.
    10. Sengupta, S.; den Boon, J.A.; Chen, I.H.; Newton, M.A.; Dahl, D.B.; Chen, M.; Cheng, Y.J.; Westra, W.H.; Chen, C.J.; Hildesheim, A.; Sugden, B.; Ahlquist, P. Genome-Wide expression Profiling Reveals EBV-Associated Inhibition of MHC Class I expression in Nasopharyngeal Carcinoma. Cancer Res. 2006 Aug 15;66(16):7999-8006.
    11. Thunnissen, F.B.; Kerr, K.M.; Brambilla, E.; Comin, C.E.; Franklin, W.A.; Guldhammer, B.; Westra, W.H.; Flieder, D.B. EU-USA pathology panel for uniform diagnosis in randomised controlled trials for HRCT screening of lung cancer. Eur Respir J. 2006 Aug 9;28:1186-1189.
    12. Upadhyay, S.; Liu, C.; Chatterjee, A.; Hoque, M.O.; Kim, M.S.; Engles, J.; Westra, W.; Trink, B.; Ratovitski, E.; Sidransky, D. LKB1/STK11 Suppresses Cyclooxygenase-2 Induction and Cellular Invasion through PEA3 in Lung Cancer. Cancer Res. 2006 Aug 15;66(16):7870-7879.
    13. Westra, W.H.; Sidransky, D. Fluorescence visualization in oral neoplasia: shedding light on an old problem. Clin Cancer Res. 2006 Nov 15;12(22):6594-6597.
    14. Begum, S.; Gillison, M.L.; Nicol, T.L.; Westra, W.H. Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res. 2007 Feb 15;13(4):1186-1191.
    15. D'Souza, G.; Kreimer, A.R.; Viscidi, R.; Pawlita, M.; Fakhry, C.; Koch, W.M.; Westra, W.H.; Gillison, M.L. Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med. 2007 May 10;356(19):1944-1956.
    16. Lietman, S.A.; Prescott, N.L.; Hicks, D.G.; Westra, W.H.; Levine, M.A. SH3BP2 Is Rarely Mutated in Exon 9 in Giant Cell Lesions Outside Cherubism. Clin Orthop Relat Res. 2007 Jun;459:22-27.
    17. Liu, C.; Zhou, S.; Begum, S.; Sidransky, D.; Westra, W.H.; Brock, M.; Califano, J.A. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. Lung Cancer. 2007 Mar;55(3):303-311.
    18. Mithani, S.K.; Taube, J.M.; Zhou, S.; Smith, I.M.; Koch, W.M.; Westra, W.H.; Califano, J.A. Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4331-4335.
    19. Nayak, C.S.; Carvalho, A.L.; Jeronimo, C.; Henrique, R.; Kim, M.M.; Hoque, M.O.; Chang, S.; Jiang, W.W.; Koch, W.; Westra, W.; Sidransky, D.; Califano, J. Positive correlation of tissue inhibitor of metalloproteinase-3 and death-associated protein kinase hypermethylation in head and neck squamous cell carcinoma. Laryngoscope. 2007 Aug;117(8):1376-1380.
    20. Poeta, M.L.; Manola, J.; Goldwasser, M.A.; Forastiere, A.; Benoit, N.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. N Engl J Med. 2007 Dec 20;357(25):2552-2561.
    21. Shah, K.V.; Westra, W.H. Genital HPVs in the aerodigestive tract: Etiologic association with a subset of oropharyngeal/tonsillar cancers and with recurrent respiratory papillomatosis. Disease markers. 2007;23(4):235-245.
    22. Taube, J.M.; Askin, F.B.; Brock, M.V.; Westra, W. Impact of elastic staining on the staging of peripheral lung cancers. Am J Surg Pathol. 2007 Jun;31(6):953-956.
    23. Westra, W.H. Diagnostic difficulties in the classification and grading of salivary gland tumors. Int J Radiat oncol Biol Phys. 2007;69(2 Suppl):S49-51.
    24. Zhou, S.; Kachhap, S.; Sun, W.; Wu, G.; Chuang, A.; Poeta, L.; Grumbine, L.; Mithani, S.K.; Chatterjee, A.; Koch, W.; Westra, W.H.; Maitra, A.; Glazer, C.; Carducci, M.; Sidransky, D.; McFate, T.; Verma, A.; Califano, J.A. Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7540-7545.
    25. Agrawal, Y.; Koch, W.M.; Xiao, W.; Westra, W.H.; Trivett, A.L.; Symer, D.E.; Gillison, M.L. Oral human papillomavirus infection before and after treatment for human papillomavirus 16-positive and human papillomavirus 16-negative head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Nov 1;14(21):7143-7150.
    26. Begum, S.; Westra, W.H. Basaloid squamous cell carcinoma of the head and neck is a mixed variant that can be further resolved by HPV status. Am J Surg Pathol. 2008;32:1044-1050.
    27. Borowitz, M.; Westra, W.H.; Illei, P.B.; Cooley, L.D.; Kant, J.A.; Sokoll, L.J.; Chan, D.W.; Sanfilippo, F. Pathology and Laboratory Medicine. In: Abeloff; Armitage; Kastan; Niederhuberl, editors. 4th ed, Clinical Oncology. Philadelphia: W.B. Saunders; 2008.
    28. Brait, M.; Begum, S.; Carvalho, A.L.; Dasgupta, S.; Vettore, A.L.; Czerniak, B.; Caballero, O.L.; Westra, W.H.; Sidransky, D.; Hoque, M.O. Aberrant Promoter Methylation of Multiple Genes during Pathogenesis of Bladder Cancer. Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2786-2794.
    29. Carvalho, A.L.; Jeronimo, C.; Kim, M.M.; Henrique, R.; Zhang, Z.; Hoque, M.O.; Chang, S.; Brait, M.; Nayak, C.S.; Jiang, W.W.; Claybourne, Q.; Tokumaru, Y.; Lee, J.; Goldenberg, D.; Garrett-Mayer, E.; Goodman, S.; Moon, C.S.; Koch, W.; Westra, W.H.; Sidransky, D.; Califano, J.A. evaluation of promoter hypermethylation detection in body fluids as a screening/diagnosis tool for head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Jan 1;14(1):97-107.
    30. Chang, S.S.; Jiang, W.W.; Smith, I.; Poeta, L.M.; Begum, S.; Glazer, C.; Shan, S.; Westra, W.; Sidransky, D.; Califano, J.A. MicroRNA alterations in head and neck squamous cell carcinoma. Int J Cancer. 2008 Dec 15;123(12):2791-2797.
    31. Chuang, A.Y.; Chuang, T.C.; Chang, S.; Zhou, S.; Begum, S.; Westra, W.H.; Ha, P.K.; Koch, W.M.; Califano, J.A. Presence of HPV DNA in convalescent salivary rinses is an adverse prognostic marker in head and neck squamous cell carcinoma. Oral Oncol. 2008 Oct;44(10):915-919.
    32. Fakhry, C.; Westra, W.H.; Li, S.; Cmelak, A.; Ridge, J.A.; Pinto, H.; Forastiere, A.; Gillison, M.L. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst. 2008 Feb 20;100(4):261-269.
    33. Gillison, M.L.; D'Souza, G.; Westra, W.; Sugar, E.; Xiao, W.; Begum, S.; Viscidi, R. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst. 2008 Mar 19;100(6):407-420.
    34. Goldenberg, D.; Begum, S.; Westra, W.H.; Khan, Z.; Sciubba, J.; Pai, S.I.; Califano, J.A.; Tufano, R.P.; Koch, W.M. Cystic lymph node metastasis in patients with head and neck cancer: An HPV-associated phenomenon. Head Neck. 2008 Jul;30(7):898-903.
    35. Hoque, M.O.; Begum, S.; Brait, M.; Jeronimo, C.; Zahurak, M.; Ostrow, K.L.; Rosenbaum, E.; Trock, B.; Westra, W.H.; Schoenberg, M.; Goodman, S.N.; Sidransky, D. Tissue inhibitor of metalloproteinases-3 promoter methylation is an independent prognostic factor for bladder cancer. J Urol. 2008 Feb;179(2):743-747.
    36. Hoque, M.O.; Kim, M.S.; Ostrow, K.L.; Liu, J.; Wisman, G.B.; Park, H.L.; Poeta, M.L.; Jeronimo, C.; Henrique, R.; Lendvai, A.; Schuuring, E.; Begum, S.; Rosenbaum, E.; Ongenaert, M.; Yamashita, K.; Califano, J.; Westra, W.; van der Zee, A.G.; Van Criekinge, W.; Sidransky, D. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res. 2008 Apr 15;68(8):2661-2670.
    37. Licchesi, J.D.; Westra, W.H.; Hooker, C.M.; Herman, J.G. Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung. Clin Cancer Res. 2008 May 1;14(9):2570-2578.
    38. Licchesi, J.D.; Westra, W.H.; Hooker, C.M.; Machida, E.O.; Baylin, S.B.; Herman, J.G. Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis. 2008 May;29(5):895-904.
    39. Park, H.L.; Kim, M.S.; Yamashita, K.; Westra, W.; Carvalho, A.L.; Lee, J.; Jiang, W.W.; Baek, J.H.; Liu, J.; Osada, M.; Moon, C.S.; Califano, J.A.; Mori, M.; Sidransky, D. DCC promoter hypermethylation in esophageal squamous cell carcinoma. Int J Cancer. 2008 Jun 1;122(11):2498-2502.
    40. Prasad, N.B.; Somervell, H.; Tufano, R.P.; Dackiw, A.P.; Marohn, M.R.; Califano, J.A.; Wang, Y.; Westra, W.H.; Clark, D.P.; Umbricht, C.B.; Libutti, S.K.; Zeiger, M.A. Identification of genes differentially expressed in benign versus malignant thyroid tumors. Clin Cancer Res. 2008 Jun 1;14(11):3327-3337.
    41. Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most Basal-like Breast Carcinomas Demonstrate the Same Rb-/p16+ Immunophenotype as the HPV-related Poorly Differentiated Squamous Cell Carcinomas Which They Resemble Morphologically. Am J Surg Pathol. 2008 Oct 17.
    42. Taube, J.M.; Begum, S.; Shi, C.; Eshleman, J.R.; Westra, W.H. Benign Nodal Nevi Frequently Harbor the Activating V600E BRAF Mutation. Am J Surg Pathol. 2008 Nov 19.
    43. Wang, Y.; Kowalski, J.; Tsai, H.L.; Marik, R.; Prasad, N.; Somervell, H.; Lo, P.K.; Sangenario, L.E.; Dyrskjot, L.; Orntoft, T.F.; Westra, W.H.; Meeker, A.K.; Eshleman, J.R.; Umbricht, C.B.; Zeiger, M.A. Differentiating alternative splice variant patterns of human telomerase reverse transcriptase in thyroid neoplasms. Thyroid. 2008 Oct;18(10):1055-1063.
    44. Westra, W.H.; Taube, J.M.; Poeta, M.L.; Begum, S.; Sidransky, D.; Koch, W.M. Inverse Relationship between Human Papillomavirus-16 Infection and Disruptive p53 Gene Mutations in Squamous Cell Carcinoma of the Head and Neck. Clin Cancer Res. 2008 Jan 15;14(2):366-369.
    45. Zhao, M.; Begum, S.; Ha, P.K.; Westra, W.; Califano, J. Downregulation of RAD17 in head and neck cancer. Head Neck. 2008 Jan;30(1):35-42.
    46. Adelstein, D.J.; Ridge, J.A.; Gillison, M.L.; Chaturvedi, A.K.; D''Souza, G.; Gravitt, P.E.; Westra, W.; Psyrri, A.; Kast, W.M.; Koutsky, L.A.; Giuliano, A.; Krosnick, S.; Trotti, A.; Schuller, D.E.; Forastiere, A.; Ullmann, C.D. Head and neck squamous cell cancer and the human papillomavirus: summary of a National Cancer Institute State of the Science Meeting, November 9-10, 2008, Washington, D.C. Head Neck. 2009 Nov;31(11):1393-1422.
    47. Ostrow, K.L.; Park, H.L.; Hoque, M.O.; Kim, M.S.; Liu, J.; Argani, P.; Westra, W.; Van Criekinge, W.; Sidransky, D. Pharmacologic unmasking of epigenetically silenced genes in breast cancer. Clin Cancer Res. 2009 Feb 15;15(4):1184-1191.
    48. Pai, S.I.; Westra, W.H. Molecular Pathology of Head and Neck Cancer: Implications for Diagnosis, Prognosis, and Treatment. Annu Rev Pathol. 2009 Aug 26;4:49-70.
    49. Poeta, M.L.; Manola, J.; Goldenberg, D.; Forastiere, A.; Califano, J.A.; Ridge, J.A.; Goodwin, J.; Kenady, D.; Saunders, J.; Westra, W.; Sidransky, D.; Koch, W.M. The Ligamp TP53 Assay for Detection of Minimal Residual Disease in Head and Neck Squamous Cell Carcinoma Surgical Margins. Clin Cancer Res. 2009 Dec 15;15(24):7658-7665.
    50. Subhawong, A.P.; Subhawong, T.; Nassar, H.; Kouprina, N.; Begum, S.; Vang, R.; Westra, W.H.; Argani, P. Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically. Am J Surg Pathol. 2009 Feb;33(2):163-175.
    51. Ang, K.K.; Harris, J.; Wheeler, R.; Weber, R.; Rosenthal, D.I.; Nguyen-Tan, P.F.; Westra, W.H.; Chung, C.H.; Jordan, R.C.; Lu, C.; Kim, H.; Axelrod, R.; Silverman, C.C.; Redmond, K.P.; Gillison, M.L. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med. 2010 Jul 1;363(1):24-35.
    52. Bishop, J.A.; Westra, W.H. Plasmablastic lymphoma involving the parotid gland. Head and neck pathology. 2010 Jun;4(2):148-151.
    53. Dasgupta, S.; Koch, R.; Westra, W.H.; Califano, J.A.; Ha, P.K.; Sidransky, D.; Koch, W.M. Mitochondrial DNA mutation in normal margins and tumors of recurrent head and neck squamous cell carcinoma patients. Cancer Prev Res (Phila). 2010 Sep;3(9):1205-1211.
    54. Durr, M.L.; Mydlarz, W.K.; Shao, C.; Zahurak, M.L.; Chuang, A.Y.; Hoque, M.O.; Westra, W.H.; Liegeois, N.J.; Califano, J.A.; Sidransky, D.; Ha, P.K. Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. PLoS One. 2010;5(5):e10828.
    55. Hoque, M.O.; Brait, M.; Rosenbaum, E.; Poeta, M.L.; Pal, P.; Begum, S.; Dasgupta, S.; Carvalho, A.L.; Ahrendt, S.A.; Westra, W.H.; Sidransky, D. Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer. J Thorac Oncol. 2010 Dec;5(12):1887-1893.
    56. Loyo, M.; Brait, M.; Kim, M.S.; Ostrow, K.L.; Jie, C.C.; Chuang, A.Y.; Califano, J.A.; Liegeois, N.J.; Begum, S.; Westra, W.H.; Hoque, M.O.; Tao, Q.; Sidransky, D. A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma. Int J Cancer. 2010 May 6.
    57. Loyo, M.; Guerrero-Preston, R.; Brait, M.; Hoque, M.O.; Chuang, A.; Kim, M.S.; Sharma, R.; Liegeois, N.J.; Koch, W.M.; Califano, J.A.; Westra, W.H.; Sidransky, D. Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission. Int J Cancer. 2010 Jun 15;126(12):2991-2996.
    58. Lyford-Pike, S.; Westra, W.H.; Loyo, M.; Peng, S.; Hung, C.F.; Wu, A.A.; Flint, P.W.; Tunkel, D.E.; Saunders, J.R.; Pai, S.I. Differential expression of epidermal growth factor receptor in juvenile and adult-onset recurrent respiratory papillomatosis. Histopathology. 2010 Nov;57(5):768-770.
    59. Marur, S.; D''Souza, G.; Westra, W.H.; Forastiere, A.A. HPV-associated head and neck cancer: a virus-related cancer epidemic. Lancet Oncol. 2010 Aug;11(8):781-789.
    60. Meguid, R.A.; Hooker, C.M.; Harris, J.; Xu, L.; Westra, W.H.; Sherwood, J.T.; Sussman, M.; Cattaneo, S.M., 2nd; Shin, J.; Cox, S.; Christensen, J.; Prints, Y.; Yuan, N.; Zhang, J.; Yang, S.C.; Brock, M.V. Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokers. Chest. 2010 Sep;138(3):500-509.
    61. Nichols, A.C.; Finkelstein, D.M.; Faquin, W.C.; Westra, W.H.; Mroz, E.A.; Kneuertz, P.; Begum, S.; Michaud, W.A.; Busse, P.M.; Clark, J.R.; Rocco, J.W. Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer. Clin Cancer Res. 2010 Apr 1;16(7):2138-2146.
    62. Singhi, A.D.; Westra, W.H. Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience. Cancer. 2010 May 1;116(9):2166-2173.
    63. Wang, C.C.; Friedman, L.; Kennedy, G.C.; Wang, H.; Kebebew, E.; Steward, D.L.; Zeiger, M.A.; Westra, W.H.; Wang, Y.; Khanafshar, E.; Fellegara, G.; Rosai, J.; Livolsi, V.; Lanman, R.B. A Large Multicenter Correlation Study of Thyroid Nodule Cytopathology and Histopathology. Thyroid. 2010 Dec 29.
在研临床试验：
Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx http://clinicaltrials.gov/show/NCT01088802
Immunologic Responses in HPV-Associated Carcinoma for Patients Receiving Chemoradiation http://clinicaltrials.gov/show/NCT01958515
核心设备：
Pathology Core Facility, Specialized Program of Research Excellence (SPORE) in Cancer of the Head and Neck
学术活动和荣誉：
《耳鼻喉科档案-头颈外科》专栏编辑

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