对于肺癌治疗进行实验胚胎学研究，肺癌和食道癌的肿瘤生物学研究，癌症检验的预测生物标记物，癌症患者结局预判和化疗敏感度评价，多汗症，器官移植的临床基础研究

Malcolm V. Brock博士毕业于约翰霍普金斯大学医学院，曾于约翰霍普金斯医院外科担任住院医师，约翰霍普金斯医院心胸外科研究员。他是胸部肿瘤外科专家，约翰霍普金斯肿瘤外科副教授。除了临床胸部肿瘤，他的临床兴趣还包括手掌，腋窝和足部多汗症的治疗。

Malcolm V. Broc博士是美国普通外科委员会委员，也是美国胸外科委员会委员。他是约翰霍普金斯医院Sidney Kimmel综合癌症中心专门从事癌症外科手术研究的医生，经常为本领域带来一些基础性的创新，无论是在临床方面还是在其他方面。他的主要的研究兴趣包括在实体肿瘤的治疗中发展创新型分子生物标志物，帮助临床医生更早的诊断出癌症，以使对于癌症的治疗更加有效。最近，他的试验室在临床中应用了一项DNA技术的基础研究成果，该项成果能够预测哪些肺癌病人在成功的进行了手术之后还会复发，预测那些食道癌病人会对于特定的化疗药物治疗敏感。他这这项工作，最近已经被广为认同，并在《新英格兰医学》杂志上发表。Dr Brock已经发表了超过70片原创的研究论文，编写了相关书籍的章节和总结其他研究人员的研究成果，并经常被邀请在国家和国际的会议发表自己的最新研究进展。

Dr Brock是在研着多项基金的受资助者，有国家健康研究基金项目、美国肿瘤外科协会项目和外科肿瘤学协会项目等。作为胸外科领域研究的权威专家，他在本领域的研究成果丰硕。

Malcolm V. Brock博士毕业于约翰霍普金斯大学医学院(巴尔的摩)，临床医学博士(MD)(1991)

约翰霍普金斯大学医学院(巴尔的摩)，住院医师(2000)

美国胸外科委员会委员(2003)

研究概况：Dr. Brock's的研究主要集中于发展和临床应用分子标记物，即DNA甲基化，以更好的实施早期的检测，精确诊断和明确肺癌和食道癌的特效的化学敏感药物。目前的研究项目包括应用DNA甲基化作为更加精确的淋巴转移的分子指示物在一组肺癌患者，作为一种预测食道癌对于新辅助化疗敏感性的方法。Dr. Brock与癌症中心肿瘤生物学科Drs. Stephen Baylin和James Herman积极合作，Dr. Brock已经得到国家卫生研究所的资助开展了艾滋病患者的肺癌发病率上升的临床研究和肿瘤分析项目。最后，Dr. Brock的实验室已经开发出肺癌和食道癌患者的大量相关数据，并匹配生物样品证实生物标记物的发现。

Brock, M.V.; Hooker, C.M.; Engels, E.A.; Moore, R.D.; Gillison, M.L.; Alberg, A.J.; Keruly, J.C.; Yang, S.C.; Heitmiller, R.F.; Baylin, S.B.; Herman, J.G.; Brahmer, J.R. Delayed diagnosis and elevated mortality in an urban population with HIV and lung cancer: implications for patient care. J Acquir Immune Defic Syndr. 2006 Sep;43(1):47-55.



Chan, C.W.; Crafton, E.; Fan, H.N.; Flook, J.; Yoshimura, K.; Skarica, M.; Brockstedt, D.; Dubensky, T.W.; Stins, M.F.; Lanier, L.L.; Pardoll, D.M.; Housseau, F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nat Med. 2006 Feb;12(2):207-213.



Engels, E.A.; Brock, M.V.; Chen, J.; Hooker, C.M.; Gillison, M.; Moore, R.D. Elevated incidence of lung cancer among HIV-infected individuals. J Clin Oncol. 2006 Mar 20;24(9):1383-1388.



Gallia, G.L.; Rand, V.; Siu, I.M.; Eberhart, C.G.; James, C.D.; Marie, S.K.; Oba-Shinjo, S.M.; Carlotti, C.G.; Caballero, O.L.; Simpson, A.J.; Brock, M.V.; Massion, P.P.; Carson, B.S., Sr.; Riggins, G.J. PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol Cancer Res. 2006 Oct;4(10):709-714.



Guo, M.; House, M.G.; Akiyama, Y.; Qi, Y.; Capagna, D.; Harmon, J.; Baylin, S.B.; Brock, M.V.; Herman, J.G. Hypermethylation of the GATA gene family in esophageal cancer. Int J Cancer. 2006 Nov 1;119(9):2078-2083.



Guo, M.; Ren, J.; House, M.G.; Qi, Y.; Brock, M.V.; Herman, J.G. Accumulation of promoter methylation suggests epigenetic progression in squamous cell carcinoma of the esophagus. Clin Cancer Res. 2006 Aug 1;12(15):4515-4522.



Machida, E.O.; Brock, M.V.; Hooker, C.M.; Nakayama, J.; Ishida, A.; Amano, J.; Picchi, M.A.; Belinsky, S.A.; Herman, J.G.; Taniguchi, S.; Baylin, S.B. Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. Cancer Res. 2006 Jun 15;66(12):6210-6218.



Montgomery, E.; Mamelak, A.J.; Gibson, M.; Maitra, A.; Sheikh, S.; Amr, S.S.; Yang, S.; Brock, M.; Forastiere, A.; Zhang, S.; Murphy, K.M.; Berg, K.D. Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions. Appl Immunohistochem Mol Morphol. 2006 Mar;14(1):24-30.



Singh, A.; Misra, V.; Thimmulappa, R.K.; Lee, H.; Ames, S.; Hoque, M.O.; Herman, J.G.; Baylin, S.B.; Sidransky, D.; Gabrielson, E.; Brock, M.V.; Biswal, S. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med. 2006 Oct;3(10):e420.



Weiss, E.S.; Doty, J.; Brock, M.V.; Halvorson, L.; Yang, S.C. A case of ectopic parathyroid hormone production by a pulmonary neoplasm. J Thorac Cardiovasc Surg. 2006 Apr;131(4):923-924.



Yoshimura, K.; Jain, A.; Allen, H.E.; Laird, L.S.; Chia, C.Y.; Ravi, S.; Brockstedt, D.G.; Giedlin, M.A.; Bahjat, K.S.; Leong, M.L.; Slansky, J.E.; Cook, D.N.; Dubensky, T.W.; Pardoll, D.M.; Schulick, R.D. selecive targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes. Cancer Res. 2006 Jan 15;66(2):1096-1104.



Brock, M.V.; Herman, J.G.; Baylin, S.B. Cancer as a manifestation of aberrant chromatin structure. Cancer J. 2007 Jan-Feb;13(1):3-8.



Engel, L.S.; Laden, F.; Andersen, A.; Strickland, P.T.; Blair, A.; Needham, L.L.; Barr, D.B.; Wolff, M.S.; Helzlsouer, K.; Hunter, D.J.; Lan, Q.; Cantor, K.P.; Comstock, G.W.; Brock, J.W.; Bush, D.; Hoover, R.N.; Rothman, N. Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin's lymphoma: a report from three cohorts. Cancer Res. 2007 Jun 1;67(11):5545-5552.



Gibbons, M.C.; Brock, M.; Alberg, A.J.; Glass, T.; LaVeist, T.A.; Baylin, S.; Levine, D.; Fox, C.E. The sociobiologic integrative model (SBIM): enhancing the integration of sociobehavioral, environmental, and biomolecular knowledge in urban health and disparities research. J Urban Health. 2007 Mar;84(2):198-211.



Goldberg, M.V.; Maris, C.H.; Hipkiss, E.L.; Flies, A.S.; Zhen, L.; Tuder, R.M.; Grosso, J.F.; Harris, T.J.; Getnet, D.; Whartenby, K.A.; Brockstedt, D.G.; Dubensky, T.W., Jr.; Chen, L.; Pardoll, D.M.; Drake, C.G. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood. 2007 Jul 1;110(1):186-192.



Guo, M.; House, M.G.; Suzuki, H.; Ye, Y.; Brock, M.V.; Lu, F.; Liu, Z.; Rustgi, A.K.; Herman, J.G. Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. Int J Cancer. 2007 Sep 15;121(6):1219-1226.



Liu, C.; Zhou, S.; Begum, S.; Sidransky, D.; Westra, W.H.; Brock, M.; Califano, J.A. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer. Lung Cancer. 2007 Mar;55(3):303-311.



Madar, I.; Bencherif, B.; Lever, J.; Heitmiller, R.F.; Yang, S.C.; Brock, M.; Brahmer, J.; Ravert, H.; Dannals, R.; Frost, J.J. Imaging delta- and mu-opioid receptors by PET in lung carcinoma patients. J Nucl Med. 2007 Feb;48(2):207-213.



Sherwood, J.T.; Brock, M.V. Lung cancer: new surgical approaches. Respirology. 2007 May;12(3):326-332.



Taube, J.M.; Askin, F.B.; Brock, M.V.; Westra, W. Impact of elastic staining on the staging of peripheral lung cancers. Am J Surg Pathol. 2007 Jun;31(6):953-956.



Brock, M.V.; Hooker, C.M.; Ota-Machida, E.; Han, Y.; Guo, M.; Ames, S.; Glockner, S.; Piantadosi, S.; Gabrielson, E.; Pridham, G.; Pelosky, K.; Belinsky, S.A.; Yang, S.C.; Baylin, S.B.; Herman, J.G. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med. 2008 Mar 13;358(11):1118-1128.



Daniels, J.A.; Gibson, M.K.; Xu, L.; Sun, S.; Canto, M.I.; Heath, E.; Wang, J.; Brock, M.; Montgomery, E. Gastrointestinal tract epithelial changes associated with taxanes: marker of drug toxicity versus effect. Am J Surg Pathol. 2008 Mar;32(3):473-477.



Forastiere, A.A.; Ang, K.K.; Brizel, D.; Brockstein, B.E.; Burtness, B.A.; Cmelak, A.J.; Colevas, A.D.; Dunphy, F.; Eisele, D.W.; Goepfert, H.; Hicks, W.L., Jr.; Kies, M.S.; Lydiatt, W.M.; Maghami, E.; Martins, R.; McCaffrey, T.; Mittal, B.B.; Pfister, D.G.; Pinto, H.A.; Posner, M.R.; Ridge, J.A.; Samant, S.; Schuller, D.E.; Shah, J.P.; Spencer, S.; Trotti, A., 3rd; Weber, R.S.; Wolf, G.T.; Worden, F. Head and neck cancers. J Natl Compr Canc Netw. 2008 Aug;6(7):646-695.



Guo, M.; Ren, J.; Brock, M.V.; Herman, J.G.; Carraway, H.E. Promoter methylation of HIN-1 in the progression to esophageal squamous cancer. Epigenetics. 2008 Nov;3(6):336-341.



Kleinberg, L.R.; Brock, M.V.; Jagannath, S.B.; Forastiere, A.A. Cancer of the Esophagus. In: Abeloff, M.e.a., editor. 4th Edition ed, Clinical Oncology. New York, NY: Churchill-Livingstone; 2008.



Meguid, R.A.; Brooke, B.S.; Chang, D.C.; Sherwood, J.T.; Brock, M.V.; Yang, S.C. Are surgical outcomes for lung cancer resections improved at teaching hospitals? Ann Thorac Surg. 2008 Mar;85(3):1015-1024; discussion 1024-1015.



Argiris, A.; Buchanan, A.; Brockstein, B.; Kolesar, J.; Ghebremichael, M.; Pins, M.; Hahn, K.; Axelrod, R.; Forastiere, A. Docetaxel and irinotecan in recurrent or metastatic head and neck cancer: a phase 2 trial of the Eastern Cooperative oncology Group. Cancer. 2009 Oct 1;115(19):4504-4513.



Jiang, T.; Collins, B.J.; Jin, N.; Watkins, D.N.; Brock, M.V.; Matsui, W.; Nelkin, B.D.; Ball, D.W. Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Res. 2009 Feb 1;69(3):845-854.



Meguid, R.A.; Hooker, C.M.; Taylor, J.T.; Kleinberg, L.R.; Cattaneo, S.M., 2nd; Sussman, M.S.; Yang, S.C.; Heitmiller, R.F.; Forastiere, A.A.; Brock, M.V. Recurrence after neoadjuvant chemoradiation and surgery for esophageal cancer: does the pattern of recurrence differ for patients with complete response and those with partial or no response? J Thorac Cardiovasc Surg. 2009 Dec;138(6):1309-1317.



Meguid, R.A.; Weiss, E.S.; Chang, D.C.; Brock, M.V.; Yang, S.C. The effect of volume on esophageal cancer resections: what constitutes acceptable resection volumes for centers of excellence? J Thorac Cardiovasc Surg. 2009 Jan;137(1):23-29.



Tjiang, T.; B.J., C.; Jin, N.; Brock, M.V.; Watkins, D.N.; Matsui, W.; Nelkin, B.D.; Ball, D.W. ASCL1 regulates CD133 and tumor-initiating capacity of SCLC. Cancer Research. 2009 (In Press).



Bailey, V.J.; Keeley, B.P.; Zhang, Y.; Ho, Y.P.; Easwaran, H.; Brock, M.V.; Pelosky, K.L.; Carraway, H.E.; Baylin, S.B.; Herman, J.G.; Wang, T.H. Enzymatic incorporation of multiple dyes for increased sensitivity in QD-FRET sensing for DNA methylation detection. Chembiochem. 2010 Jan 4;11(1):71-74.



Bailey, V.J.; Zhang, Y.; Keeley, B.P.; Yin, C.; Pelosky, K.L.; Brock, M.; Baylin, S.B.; Herman, J.G.; Wang, T.H. Single-tube analysis of DNA methylation with silica superparamagnetic beads. Clin Chem. 2010 Jun;56(6):1022-1025.



Bhattacharya, R.; Kowalski, J.; Larson, A.R.; Brock, M.; Alani, R.M. Id1 promotes tumor cell migration in nonsmall cell lung cancers. J Oncol. 2010;2010:856105.